Kim H S, Kim Y H, Hong Y S, Paek N S, Lee H S, Kim T H, Kim K W, Lee J J
Planta Med. 1999 Jun;65(5):437-9. doi: 10.1055/s-2006-960803.
A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyranosyl alpha-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.
鸭跖草的甲醇提取物对α-葡萄糖苷酶显示出强效抑制活性。通过生物活性导向的分级分离，分离出一种吡咯烷生物碱2,5-二羟甲基-3,4-二羟基吡咯烷（DMDP，1）和四种哌啶生物碱1-脱氧甘露基野尻霉素（2）、1-脱氧野尻霉素（3）、α-高野尻霉素（4）和7-O-β-D-吡喃葡萄糖基α-高野尻霉素（5）。这些化合物首次从鸭跖草中被鉴定出来，为这种作为传统草药用于治疗糖尿病的植物提供了药理学依据。
