Takada Kentaro, Uehara Taisuke, Nakao Yoichi, Matsunaga Shigeki, van Soest Rob W M, Fusetani Nobuhiro
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
J Am Chem Soc. 2004 Jan 14;126(1):187-93. doi: 10.1021/ja037368r.
Three new alpha-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C(28) fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit alpha-glucosidase with IC(50) values of 48-170 nM.
从海洋海绵舒氏笔海绵（Penares schulzei）中分离出三种新的α-葡萄糖苷酶抑制剂，舒氏碱A - C（1 - 3）。通过光谱分析和化学降解确定了它们的结构，为异喹啉生物碱，包含两个氨基酸和C(28)脂肪酸，后者为硫酸化形式。通过将改良的莫舍分析法应用于化学降解得到的片段，确定了舒氏碱的绝对立体化学。舒氏碱A - C对α-葡萄糖苷酶具有抑制作用，IC(50)值为48 - 170 nM。
