Hansson V, Skålhegg B S, Taskén K
Institute of Medical Biochemistry, University of Oslo, Norway.
J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):367-78. doi: 10.1016/s0960-0760(99)00077-1.
LH and FSH regulate via cyclic adenosine 3'5' cyclic monophosphate (cAMP) and cAMP-dependent protein kinase (PKA), steroid biosynthesis is Leydig and Sertoli cells, respectively. Cyclic AMP also regulates a number of different cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters, and gene transcription. The principle intracellular target for cAMP in mammalian cells is the PKA. The fact that this broad specificity protein kinase mediates a number of discrete physiological responses following cAMP engagement, has raised the question of how specificity is maintained in the cAMP/PKA system. Here we describe features of this signaling pathway that may contribute to explain how differential effects of cAMP may be contributed to features of the PKA signaling pathway.
促黄体生成素（LH）和促卵泡生成素（FSH）分别通过环磷酸腺苷（cAMP）和cAMP依赖性蛋白激酶（PKA）调节睾丸间质细胞和支持细胞中的类固醇生物合成。环磷酸腺苷还调节许多不同的细胞过程，如细胞生长和分化、离子通道传导性、神经递质的突触释放以及基因转录。在哺乳动物细胞中，cAMP的主要细胞内靶点是PKA。这种具有广泛特异性的蛋白激酶在cAMP结合后介导许多离散的生理反应，这就提出了一个问题，即cAMP/PKA系统如何保持特异性。在这里，我们描述了该信号通路的一些特征，这些特征可能有助于解释cAMP的不同作用是如何归因于PKA信号通路的特征的。
