Svechnikov K, Izzo G, Landreh L, Weisser J, Söder O
Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Q2:08, E-17176 Stockholm, Sweden.
J Biomed Biotechnol. 2010;2010. doi: 10.1155/2010/684504. Epub 2010 Aug 25.
During the past decades, a large body of information concerning the effects of endocrine disrupting compounds (EDCs) on animals and humans has been accumulated. EDCs are of synthetic or natural origin and certain groups are known to disrupt the action of androgens and to impair the development of the male reproductive tract and external genitalia. The present overview describes the effects of the different classes of EDCs, such as pesticides, phthalates, dioxins, and phytoestrogens, including newly synthesized resveratrol analogs on steroidogenesis in Leydig cells. The potential impact of these compounds on androgen production by Leydig cells during fetal development and in the adult age is discussed. In addition, the possible role of EDCs in connection with the increasing frequency of abnormalities in reproductive development in animals and humans is discussed.
在过去几十年里，已经积累了大量关于内分泌干扰化合物（EDCs）对动物和人类影响的信息。EDCs来源于合成或天然，已知某些类别会干扰雄激素的作用，并损害雄性生殖道和外生殖器的发育。本综述描述了不同类别的EDCs，如农药、邻苯二甲酸盐、二恶英和植物雌激素，包括新合成的白藜芦醇类似物对睾丸间质细胞类固醇生成的影响。讨论了这些化合物在胎儿发育和成体期对睾丸间质细胞雄激素产生的潜在影响。此外，还讨论了EDCs在动物和人类生殖发育异常频率增加方面可能发挥的作用。
