White P C, Hautanen A, Kupari M
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):409-12. doi: 10.1016/s0960-0760(99)00071-0.
In addition to regulating renal sodium resorption and, thus, intravascular volume, aldosterone may have direct effects on the cardiovascular system. We previously identified a polymorphism (-344C/T) in the promoter of the aldosterone synthase (CYP11B2) gene that affects binding of the SF-1 transcription factor and thus might influence gene expression. We found that, whereas this polymorphism has inconsistent associations with levels of aldosterone secretion and blood pressure, the -344C allele is strongly associated with increased left ventricular size and decreased baroreflex sensitivity in healthy individuals. These physiological parameters are cardiovascular risk factors. Indeed, preliminary studies suggest that the -344C allele is also associated with increased risk of myocardial infarction in high risk dyslipidemic males.
除了调节肾脏对钠的重吸收，进而调节血管内容量外，醛固酮可能对心血管系统有直接作用。我们之前在醛固酮合成酶（CYP11B2）基因启动子中鉴定出一种多态性（-344C/T），它会影响SF-1转录因子的结合，因此可能影响基因表达。我们发现，虽然这种多态性与醛固酮分泌水平和血压的关联并不一致，但在健康个体中，-344C等位基因与左心室增大及压力反射敏感性降低密切相关。这些生理参数都是心血管危险因素。事实上，初步研究表明，-344C等位基因在高危血脂异常男性中也与心肌梗死风险增加有关。
