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醛固酮合成酶（CYP11B2）-344 T/C多态性与糖尿病肾病的关联：一项荟萃分析。

Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis.

作者信息

Xu Haiyan, Wang Xu, Liu Mingming, Shao Xin, He Xueyuan

机构信息

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China

出版信息

J Renin Angiotensin Aldosterone Syst. 2016 Mar 23;17(1):1470320316633896. doi: 10.1177/1470320316633896. Print 2016 Jan-Mar.

DOI:10.1177/1470320316633896
PMID:27009287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5843876/
Abstract

INTRODUCTION

Studies on the relation between aldosterone synthase -344 T/C polymorphism and diabetic nephropathy showed controversial conclusions. This meta-analysis aimed to systematically summarize the association between aldosterone synthase (CYP11B2) gene polymorphism and diabetic nephropathy risk.

METHODS

Embase, PubMed, ScienceDirect, Web of Science, Wanfang Data, VIP Database, China Knowledge Resource Integrated Database and SinoMed have been searched. A total of five studies including 825 cases and 910 controls were included.

RESULTS

In overall analysis, significant increased risk was found in recessive comparison (OR = 1.27, 95% CI 1.05-1.55), homozygote comparison (OR = 1.39, 95% CI 1.04-1.88) and allele comparison (OR = 1.20, 95% CI = 1.05-1.39). No significant association was detected in dominant comparison (OR = 1.27, 95% CI 0.97-1.66) and heterozygote comparison (OR = 1.17, 95% CI 0.88-1.56). In subgroup analysis, significant increased risk existed in Asian population in allele comparison (OR = 1.45, 95% CI = 1.17-1.79), dominant comparison (OR = 1.78, 95% CI 1.11-2.87), homozygote comparison (OR = 2.11, 95% CI 1.29-3.47), recessive comparison (OR = 1.54, 95% CI 1.17-2.03), except for heterozygote comparison (OR = 1.44, 95% CI 0.87-2.38).

CONCLUSIONS

Our meta-analysis indicates that aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor.

摘要

引言

关于醛固酮合酶-344 T/C多态性与糖尿病肾病之间关系的研究得出了相互矛盾的结论。本荟萃分析旨在系统总结醛固酮合酶（CYP11B2）基因多态性与糖尿病肾病风险之间的关联。

方法

检索了Embase、PubMed、ScienceDirect、Web of Science、万方数据、维普数据库、中国知网和中国生物医学文献数据库。共纳入五项研究，包括825例病例和910例对照。

结果

在总体分析中，隐性比较（OR = 1.27，95% CI 1.05 - 1.55）、纯合子比较（OR = 1.39，95% CI 1.04 - 1.88）和等位基因比较（OR = 1.20，95% CI = 1.05 - 1.39）中发现风险显著增加。显性比较（OR = 1.27，95% CI 0.97 -

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/e6e7a751ef79/10.1177_1470320316633896-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/48712b410d59/10.1177_1470320316633896-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/5e6166225d96/10.1177_1470320316633896-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/e3dff2480bd1/10.1177_1470320316633896-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/8f6e88ed0382/10.1177_1470320316633896-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/e6e7a751ef79/10.1177_1470320316633896-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/48712b410d59/10.1177_1470320316633896-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/5e6166225d96/10.1177_1470320316633896-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/e3dff2480bd1/10.1177_1470320316633896-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/8f6e88ed0382/10.1177_1470320316633896-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f85/5843876/e6e7a751ef79/10.1177_1470320316633896-fig5.jpg

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