Ghose R P, Hall P M, Bravo E L
Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Ohio 44195, USA.
Ann Intern Med. 1999 Jul 20;131(2):105-8. doi: 10.7326/0003-4819-131-2-199907200-00005.
No data are available on the long-term medical management of aldosterone-producing adenomas.
To demonstrate the efficacy of medical management of aldosterone-producing adenomas in terms of blood pressure and serum potassium concentration and to discuss morbidity associated with medical management.
Retrospective cohort study.
Large tertiary care referral center.
24 patients with documented aldosterone-producing adenomas who were treated medically for at least 5 years.
Aldosterone excretion rate, plasma renin activity, and size and location of adenomas (by computed tomography). Blood pressure and serum electrolytes were measured at the time of diagnosis and last follow-up.
From the time of diagnosis to the time of last follow-up, systolic blood pressure decreased from 175 mm Hg to 129 mm Hg (95% CI for difference, 37.1 to 53.8 mm Hg) and diastolic blood pressure decreased from 106 mm Hg to 79 mm Hg (CI for difference, 20.8 to 33.9 mm Hg). Serum potassium concentration increased from 3.0 mmol/L to 4.3 mmol/L (CI for difference, 1.1 to 1.5 mmol/L).
Medical management of aldosterone-producing adenomas is a viable option for controlling blood pressure and serum potassium concentration.
目前尚无关于醛固酮瘤长期药物治疗的数据。
证明醛固酮瘤药物治疗在血压和血清钾浓度方面的疗效，并讨论药物治疗相关的发病率。
回顾性队列研究。
大型三级医疗转诊中心。
24例经证实患有醛固酮瘤且接受至少5年药物治疗的患者。
醛固酮排泄率、血浆肾素活性以及腺瘤的大小和位置（通过计算机断层扫描）。在诊断时和末次随访时测量血压和血清电解质。
从诊断到末次随访，收缩压从175 mmHg降至129 mmHg（差值的95%可信区间为37.1至53.8 mmHg），舒张压从106 mmHg降至79 mmHg（差值的可信区间为20.8至33.9 mmHg）。血清钾浓度从3.0 mmol/L升至4.3 mmol/L（差值的可信区间为1.1至1.5 mmol/L）。
醛固酮瘤的药物治疗是控制血压和血清钾浓度的可行选择。
