Nakamura H, Yoshino S, Kato T, Tsuruha J, Nishioka K
Rheumatology, Immunology, Genetic Program, Institute of Medical Science, St. Marianna University School of Medicine, Kawsasaki, Japan.
Osteoarthritis Cartilage. 1999 Jul;7(4):401-2. doi: 10.1053/joca.1998.0224.
Osteoarthritis (OA) is not caused by a simple consequence of aging and cartilage degradation. Based on the conventional paradigm, OA has been considered a degenerative joint disorder. However, the dominant clinical symptom has been characterized by a non-infectious chronic inflammatory condition with infiltration of inflammatory cells in the synovial tissue or synovial fluid, especially in the early stage of the disease. The inflammatory process appeared to develop degeneration of chondrocytes and/or formation of osteophytes. Immunohistochemical staining of synovial tissue with OA in the early stage, suggests the presence of T-cell infiltration in the perivascular area, some of which were CD4 positive T cells. Among the T cells, we identified the clonality of restricted TCR usage of Vbeta chain by single strand conformation polymorphism (SSCP) method on T-cell repertoire. Therefore we address the immune response in primary OA.
骨关节炎（OA）并非由衰老和软骨退化的简单后果引起。基于传统范式，OA一直被认为是一种退行性关节疾病。然而，主要的临床症状表现为一种非感染性慢性炎症状态，炎症细胞浸润于滑膜组织或滑液中，尤其是在疾病的早期阶段。炎症过程似乎会导致软骨细胞退变和/或骨赘形成。对早期OA滑膜组织进行免疫组织化学染色，提示在血管周围区域存在T细胞浸润，其中一些是CD4阳性T细胞。在T细胞中，我们通过单链构象多态性（SSCP）方法对T细胞库中Vβ链受限的TCR使用克隆性进行了鉴定。因此，我们探讨了原发性OA中的免疫反应。
