Bots M L, van Kooten F, Breteler M M, Slagboom P E, Hofman A, Haverkate F, Meijer P, Koudstaal P J, Grobbee D E, Kluft C
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
Haemostasis. 1998 May-Aug;28(3-4):209-15. doi: 10.1159/000022432.
We performed a cross-sectional case-control study among 295 subjects with dementia and 406 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, to evaluate the association of the factor V Leiden mutation and activated protein C (APC) response with dementia and its subtypes. The risk of dementia was 2.11-fold increased among carriers of factor V Leiden mutation relative to subjects lacking factor V Leiden mutation (95% confidence interval, CI, 0.93-4.77). The increased risks of vascular dementia and of Alzheimer's disease were 4.28 (95% CI 1.26-14.5) and 2.15 (95% CI 0.82-5.63), respectively. No association was found for APC response. We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden. The association appeared to be stronger for vascular dementia.
我们在295名痴呆症患者和406名对照受试者中进行了一项横断面病例对照研究，这些受试者来自鹿特丹研究（一项针对55岁及以上人群的基于人群的队列研究）的参与者，以及鹿特丹中风数据库（一个基于医院的中风登记处）的参与者，以评估凝血因子V莱顿突变和活化蛋白C（APC）反应与痴呆症及其亚型之间的关联。与缺乏凝血因子V莱顿突变的受试者相比，凝血因子V莱顿突变携带者患痴呆症的风险增加了2.11倍（95%置信区间，CI，0.93 - 4.77）。血管性痴呆和阿尔茨海默病的风险增加分别为4.28（95%CI 1.26 - 14.5）和2.15（95%CI 0.82 - 5.63）。未发现APC反应存在关联。我们发现凝血因子V莱顿突变受试者患痴呆症的风险有两倍增加，但无统计学意义。这种关联在血管性痴呆中似乎更强。
