Bots M L, Breteler M M, van Kooten F, Haverkate F, Meijer P, Koudstaal P J, Grobbee D E, Kluft C
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
Haemostasis. 1998 May-Aug;28(3-4):216-22. doi: 10.1159/000022433.
We performed a cross-sectional case-control study among 277 subjects with dementia and 298 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, with the objective to evaluate the association of indicators of coagulability, fibrinogen, prothrombin fragments 1+2, thrombin-antithrombin complex (TAT), and indicators of fibrinolysis, plasmin-inhibitor complex, D-dimer and tissue-type plasminogen activator (t-PA) with dementia. Increased levels of TAT, D-dimer and t-PA activity were associated with an increased risk of dementia. Additional stratified analyses indicated that an increased TAT level was the primary factor related to dementia. The present study provides evidence that predominantly increased thrombin generation is associated with dementia.
我们在277名痴呆症患者和298名对照受试者中进行了一项横断面病例对照研究，这些受试者来自鹿特丹研究（一项针对55岁及以上人群的基于人群的队列研究）的参与者，以及鹿特丹中风数据库（一个基于医院的中风登记处）的参与者，目的是评估凝血指标、纤维蛋白原、凝血酶原片段1+2、凝血酶-抗凝血酶复合物（TAT）以及纤维蛋白溶解指标、纤溶酶抑制剂复合物、D-二聚体和组织型纤溶酶原激活剂（t-PA）与痴呆症的关联。TAT、D-二聚体水平升高和t-PA活性与痴呆症风险增加相关。额外的分层分析表明，TAT水平升高是与痴呆症相关的主要因素。本研究提供了证据，表明主要是凝血酶生成增加与痴呆症有关。
