[萘呋胺酯（盐酸萘呋胺）对青光眼患者视神经乳头血流的影响]
[Effect of naftidrofuryl (praxilene) on optic nerve head blood flow in the patient with glaucoma].
作者信息
Achache F, Titzé P, Movaffaghy A, Mermoud A
机构信息
Hôpital Ophtalmique Jules Gonin, Lausanne.
出版信息
Klin Monbl Augenheilkd. 1999 May;214(5):260-2. doi: 10.1055/s-2008-1034786.
PURPOSE
To evaluate the effects of an S2 specific antiserotonine agent (Naftidrofuryl) on the optic nerve head blood flow in glaucomatous patient.
PATIENTS AND METHOD
11 glaucomatous subjects were enrolled in the study. After administration of 200 mg naftidrofuryl twice daily for 7 days: values of optic nerve head blood flow (Fonh), velocity and volume were recorded in the temporal rim and cup of the optic nerve head. Blood flow measurements were performed by laser doppler flow-metry at day 0 and day 7 before and one and two hours after drug administration.
RESULTS
Our study showed a significant improvement of perfusion pressure (p = 0.02) at day 7 and an increase of mean ophthalmique artery pressure (p = 0.03).
DISCUSSION
Our preliminary results on a small number of patients and a short follow-up indicate that the use of naftidrofuryl may enhance optic nerve head blood flow in glaucomatous patients. Further studies may confirm these results.
目的
评估一种S2特异性抗血清素药物（萘呋胺酯）对青光眼患者视神经乳头血流的影响。
患者与方法
11名青光眼患者参与了本研究。在每日两次服用200毫克萘呋胺酯，持续7天后：记录视神经乳头颞侧边缘和视杯处的视神经乳头血流值（Fonh）、流速和容积。在第0天和第7天，于给药前以及给药后1小时和2小时，通过激光多普勒血流仪进行血流测量。
结果
我们的研究显示，第7天时灌注压有显著改善（p = 0.02），平均眼动脉压升高（p = 0.03）。
讨论
我们对少数患者进行的短期随访初步结果表明，使用萘呋胺酯可能会增加青光眼患者的视神经乳头血流。进一步的研究可能会证实这些结果。
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