Korneev A A, Golyshevskaia V I, Sevast'ianova E V, Safonova S G, Puzanov V A
Probl Tuberk. 1999(2):44-7.
Multiresistant M. tuberculosis strains show varying drug resistance, virulence and growth rates. The count of cells of some multiresistant strains in the guinea-pig parenchymatous organs after intracardiac inoculation was comparable with that of after inoculation with clinical isolates. Furthermore, some multiresistant strains were not inferior to sensitive clinical isolates. The findings lead to the conclusion that there is a wide range in the virulence of multiresistant strains and hence they can present an epidemiological hazard.
多重耐药结核分枝杆菌菌株表现出不同程度的耐药性、毒力和生长速率。在心内接种后,一些多重耐药菌株在豚鼠实质器官中的细胞计数与接种临床分离株后的情况相当。此外,一些多重耐药菌株并不逊于敏感临床分离株。这些发现得出结论,多重耐药菌株的毒力范围很广,因此它们可能构成流行病学危害。