Zazpe A, Del Río J
Departamento de Farmacología, Facultad de Medicina, Universidad de Navarra.
Rev Med Univ Navarra. 1997 Jul-Sep;41(3):180-4.
Neurodegenerative diseases are highly devastating disorders characterized by the damage and loss of discrete neuronal populations. Until recently, it was assumed that the ability of the central nervous system to recover from injury was extremely limited. However, many "in vitro" and "in vivo" studies have shown that neurotrophic factor are able to prevent or inhibit neuronal cell death induced by a variety of insults. Accordingly, trophic factors may represent a new tool for treating neuronal injury and death in a variety of neurodegenerative diseases. In his review, the therapeutic possibilities of neurotrophins in the treatment of Parkinson's disease, Alzheimer disease and amyotrophic lateral sclerosis are analysed.
神经退行性疾病是极具破坏性的病症，其特征为离散神经元群体的损伤和丧失。直到最近，人们一直认为中枢神经系统从损伤中恢复的能力极其有限。然而，许多“体外”和“体内”研究表明，神经营养因子能够预防或抑制由多种损伤诱导的神经元细胞死亡。因此，营养因子可能代表了一种治疗多种神经退行性疾病中神经元损伤和死亡的新工具。在这篇综述中，分析了神经营养蛋白在治疗帕金森病、阿尔茨海默病和肌萎缩侧索硬化症方面的治疗可能性。
