神经营养因子与帕金森病：一位新角色的出现？

Neurotrophic factors and Parkinson's disease: the emergence of a new player?

作者信息

Dauer William

机构信息

Departments of Neurology and Pharmacology, Columbia University, Neurological Institute of New York, Box 204, 710 West 168th Street, New York, NY 10032, USA.

出版信息

Sci STKE. 2007 Nov 6;2007(411):pe60. doi: 10.1126/stke.4112007pe60.

DOI:10.1126/stke.4112007pe60

PMID:17986711

Abstract

The administration of neurotrophic factors is a potential approach to the therapy of neurodegenerative disorders such as Parkinson's disease. However, issues relating to compound delivery and potential side effects have limited the clinical application of this treatment strategy. The identification of CDNF and MANF, which constitute a new class of neurotrophic factors active against dopaminergic neurons, may provide new hope for therapeutic approaches to neurodegenerative disorders based on neurotrophic factors or downstream components of their signaling pathways.

摘要

给予神经营养因子是治疗帕金森病等神经退行性疾病的一种潜在方法。然而，与化合物递送和潜在副作用相关的问题限制了这种治疗策略的临床应用。CDNF和MANF的发现构成了一类对多巴胺能神经元有活性的新型神经营养因子，这可能为基于神经营养因子或其信号通路下游成分的神经退行性疾病治疗方法带来新希望。