酒精与仓鼠颊囊癌变

Alcohol and hamster buccal pouch carcinogenesis.

作者信息

Freedman A, Shklar G

出版信息

Oral Surg Oral Med Oral Pathol. 1978 Dec;46(6):794-805. doi: 10.1016/0030-4220(78)90311-0.

DOI:10.1016/0030-4220(78)90311-0

Abstract

Alcohol was shown to enhance the carcinogenic effect of DMBA applied to hamster buccal pouch. DMBA animals given alcohol developed dysplastic leukoplakic lesions and epidermoid carcinomas 2 weeks ahead of water-drinking control animals. The tumors also grew to larger size, were more invasive, and were more anaplastic histologically. Forty young adult Syrian hamsters were divided into four groups (alcohol-DMBA, DMBA control, untreated control, and alcohol control) and were killed after 10, 12, and 14 weeks of DMBA applications three times weekly. Alcohol was given as a 10 percent solution instead of drinking water.

摘要

研究表明，酒精会增强应用于仓鼠颊囊的二甲基苯并蒽（DMBA）的致癌作用。给予酒精的DMBA处理动物比饮用自来水的对照动物提前两周出现发育异常的白斑病变和表皮样癌。肿瘤也长得更大，侵袭性更强，组织学上间变程度更高。40只年轻成年叙利亚仓鼠被分为四组（酒精-DMBA组、DMBA对照组、未处理对照组和酒精对照组），每周三次给予DMBA，在处理10、12和14周后处死。酒精以10%的溶液形式给予，而非饮用水。

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