Ramadori G, Christ B
Department of Gastroenterology and Endocrinology, University of Göttingen, Germany.
Semin Liver Dis. 1999;19(2):141-55. doi: 10.1055/s-2007-1007106.
The acute-phase reaction comprises a variety of systemic changes in response to tissue injury and infection. Synthesis of several plasma proteins in the liver undergoes dramatic changes during the acute-phase reaction. These changes are mediated by the action of cytokines, mainly interleukin 6-(IL6-) and interleukin 1-(IL1-) type cytokines. The role of these cytokines is reviewed in detail. Attention is payed to the differences recently detected between the locally and systemically induced acute-phase response--in particular, the newest findings concerning the meaning of single cytokines. Also, changes in liver metabolic enzyme expression under acute-phase conditions are discussed. The impact of cytokine and cytokine-receptor knockout or transgenic mouse models on current knowledge is provided. The role of cytokines together with that of soluble cytokine receptors in the resolution of the acute-phase response is discussed.
急性期反应包括机体对组织损伤和感染产生的一系列全身性变化。在急性期反应过程中，肝脏中几种血浆蛋白的合成发生显著变化。这些变化由细胞因子介导，主要是白细胞介素6（IL-6）和白细胞介素1（IL-1）类细胞因子。本文详细综述了这些细胞因子的作用。重点关注了近期发现的局部诱导和全身诱导的急性期反应之间的差异，特别是关于单个细胞因子意义的最新研究结果。此外，还讨论了急性期条件下肝脏代谢酶表达的变化。阐述了细胞因子和细胞因子受体基因敲除或转基因小鼠模型对当前知识的影响。探讨了细胞因子以及可溶性细胞因子受体在急性期反应消退过程中的作用。
