Skovránková J
Ambulance ockování, Poliklinika FN Motol, Praha.
Cas Lek Cesk. 1999 May 10;138(10):298-300.
In the submitted review the author describes time correlation's of reconstitution of immunity during the post-transplantation period in patients after autologous and allogeneic bone marrow transplantations. The authors presents values of different immunological parameters incl. functional examinations of immunity by the method of blastic lymphocyte transformation after stimulation with mitogens and vaccination antigens during the post-transplantation period. She also evaluates mechanisms involved in this process. An illustrative idea on the character and degree of affection of immunity mechanisms after bone marrow transplantation is provided by the state of postvaccination immunity after immunization made before the disease and bone marrow transplantation. The titres of postvaccination antibodies after a 1-4-year interval following bone marrow transplantation gradually drop to low or zero values. The author emphasises therefore the necessity of revaccination of patients with killed vaccines against tetanus, diphtheria, poliovirus and pneumococcal, meningococcal and haemophil infection during the post-transplantation period. Recommended vaccination patterns are also presented.
在提交的综述中，作者描述了自体和异体骨髓移植患者移植后免疫重建的时间相关性。作者给出了不同免疫参数的值，包括移植后用丝裂原和疫苗抗原刺激后通过淋巴细胞转化方法进行的免疫功能检查。她还评估了这一过程中涉及的机制。疾病和骨髓移植前进行免疫接种后的疫苗接种后免疫状态，为骨髓移植后免疫机制的特征和受影响程度提供了一个说明性的概念。骨髓移植后1至4年间隔期的疫苗接种后抗体滴度逐渐降至低水平或零值。因此，作者强调在移植后期间有必要用破伤风、白喉、脊髓灰质炎病毒以及肺炎球菌、脑膜炎球菌和嗜血杆菌感染的灭活疫苗对患者进行重新接种。文中还给出了推荐的疫苗接种模式。
