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[同种异体和自体骨髓移植及再接种后针对破伤风类毒素、白喉类毒素、麻疹病毒、脊髓灰质炎病毒和肺炎球菌的疫苗抗体动力学。3:同种异体和自体骨髓移植及白喉和破伤风联合再接种后针对破伤风类毒素和白喉类毒素的疫苗抗体动力学]

[The kinetics of vaccine antibodies against tetanus toxoid, diphtheria toxoid, measles virus, poliomyelitis virus and pneumococcus after allogeneic and autologous bone marrow transplantation and revaccination. 3: The kinetics of vaccine antibodies against tetanus toxoid and diphtheria toxoid after allogeneic and autologous bone marrow transplantation and combined revaccination against diphtheria and tetanus].

作者信息

Prager J, Baumert A, Thilo W, Hermann J, Fuchs D, Sauerbrey A, Zintl F

机构信息

Universitäts-Kinderklinik Jussuf Ibrahim, Jena.

出版信息

Kinderarztl Prax. 1992 Nov;60(8):230-8.

PMID:1469826
Abstract

The 3rd part of the paper deals with the results of a combined revaccination against diphtheria and tetanus in a group of 25 children after allogeneic bone marrow transplantation (BMT) with and without graft versus host disease (GvHD) and after autologous transplantation. It can be shown that in the allogeneic transplanted groups with and without GvHD it is possible to build up a tetanus and diphtheria antitoxin titre in a safe protective cause by a 2nd basic immunisation consisting of 3 single vaccinations starting about 9 to 12 months later. For autologous transplanted children only 1 to 2 vaccinations at a later term than for the allogeneic transplanted children may possibly be sufficient.

摘要

本文的第三部分探讨了在25名接受同种异体骨髓移植(BMT)且伴有或不伴有移植物抗宿主病(GvHD)的儿童以及自体移植后的儿童中,进行白喉和破伤风联合再接种的结果。结果表明,在伴有和不伴有GvHD的同种异体移植组中,通过大约在9至12个月后开始的由3次单次接种组成的第二次基础免疫,可以建立起安全有效的破伤风和白喉抗毒素滴度。对于自体移植的儿童,比同种异体移植儿童更晚进行1至2次接种可能就足够了。

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