饮食失调的家族聚集性：神经性贪食症对照家庭研究的结果
Familial aggregation of eating disorders: results from a controlled family study of bulimia nervosa.
作者信息
Stein D, Lilenfeld L R, Plotnicov K, Pollice C, Rao R, Strober M, Kaye W H
机构信息
Western Psychiatric Institute, University of Pittsburgh School of Medicine, Pennsylvania, PA 15213, USA.
出版信息
Int J Eat Disord. 1999 Sep;26(2):211-5. doi: 10.1002/(sici)1098-108x(199909)26:2<211::aid-eat11>3.0.co;2-0.
OBJECTIVE
While familial aggregation of bulimia nervosa (BN) is known to occur, the extent to which aggregation of a broader spectrum of eating disorders (ED) occurs in the families of individuals with BN is less certain.
METHOD
Direct interviews and blind best-estimate diagnostic procedures were used to assess lifetime histories of EDs among first-degree relatives (n = 177) of probands with BN (n = 47) and first-degree relatives (n = 190) of non-ED control probands (n = 44).
RESULTS
Forty-three percent of sisters and 26% of mothers of BN probands had a lifetime ED diagnosis, with eating disorder not otherwise specified (ED-NOS) diagnoses being most common. These rates were significantly higher than among sisters (5%) and mothers (5%) of controls. Few male relatives of either cohort had an ED.
CONCLUSIONS
Diagnostic assessment using contemporary family-epidemiology methodology revealed very strong familial aggregation of a broad spectrum of EDs among female relatives of women with BN.
目的
虽然已知神经性贪食症（BN）存在家族聚集性，但在BN患者家庭中更广泛的饮食失调（ED）聚集程度尚不确定。
方法
采用直接访谈和盲法最佳估计诊断程序，评估BN先证者（n = 47）的一级亲属（n = 177）和非ED对照先证者（n = 44）的一级亲属（n = 190）的ED终生病史。
结果
BN先证者的姐妹中有43%、母亲中有26%被诊断为终生患有ED，其中未另行分类的饮食失调（ED-NOS）诊断最为常见。这些比率显著高于对照组姐妹（5%）和母亲（5%）。两组的男性亲属中很少有人患有ED。
结论
使用当代家庭流行病学方法进行的诊断评估显示，BN女性患者的女性亲属中广泛的ED存在非常强的家族聚集性。
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