饮食失调的遗传度：方法与当前研究结果
The heritability of eating disorders: methods and current findings.
作者信息
Thornton Laura M, Mazzeo Suzanne E, Bulik Cynthia M
机构信息
Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599-7160, USA.
出版信息
Curr Top Behav Neurosci. 2011;6:141-56. doi: 10.1007/7854_2010_91.
Family, twin, and adoption studies of anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), and the proposed purging disorder presentation (PD) have consistently demonstrated that genetic factors contribute to the variance in liability to eating disorders. In addition, endophenotypes and component phenotypes of eating disorders have been evaluated and provide further insight regarding genetic factors influencing eating disorders and eating disorder diagnostic criteria. Many of these phenotypes have demonstrated substantial heritability. This chapter reviews biometrical genetic methods and current findings from family and twin studies that investigate the role of genes and environment in the etiology of eating disorders. We review the methodology used to estimate heritability, the results of these studies, and discuss the implications of this research for the basic conceptualization of eating disorders and the future value of twin modeling in the molecular genetic era.
对神经性厌食症（AN）、神经性贪食症（BN）、暴饮暴食症（BED）以及拟议的清除障碍表现（PD）的家族、双生子和收养研究一致表明，遗传因素导致了饮食失调易感性的差异。此外，饮食失调的内表型和组成表型已得到评估，并为影响饮食失调和饮食失调诊断标准的遗传因素提供了进一步的见解。其中许多表型已显示出高度遗传性。本章回顾了生物统计学遗传方法以及家族和双生子研究的当前发现，这些研究调查了基因和环境在饮食失调病因中的作用。我们回顾了用于估计遗传性的方法、这些研究的结果，并讨论了这项研究对饮食失调基本概念化的意义以及双生子模型在分子遗传学时代的未来价值。
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