Sundin T, Vanhamme L, Van Hecke P, Dologlou I, Van Huffel S
Department of Systems and Control, Uppsala University, Uppsala, SE-75103, Sweden.
J Magn Reson. 1999 Aug;139(2):189-204. doi: 10.1006/jmre.1999.1782.
A scheme for accurate quantification of (1)H spectra is presented. The method uses maximum-phase finite impulse response (FIR) filters for solvent suppression and an iterative nonlinear least-squares (NLLS) algorithm for parameter estimation. The estimation algorithm takes the filter influence on the metabolites of interest into account and can thereby correctly incorporate a large variety of prior knowledge into the estimation phase. The FIR filter is designed in such a way that no distortion of the important initial samples is introduced. The FIR filter method is compared numerically with the HSVD method for water signal removal in a number of examples. The results show that the FIR method, using an automatic filter design scheme, slightly outperforms the HSVD method in most cases. The good performance and ease of use of the FIR filter method combined with its low computational complexity motivate the use of the proposed method.
提出了一种用于精确量化氢谱的方案。该方法使用最大相位有限脉冲响应（FIR）滤波器进行溶剂抑制，并使用迭代非线性最小二乘（NLLS）算法进行参数估计。估计算法考虑了滤波器对感兴趣代谢物的影响，从而可以在估计阶段正确纳入各种先验知识。FIR滤波器的设计方式是不引入重要初始样本的失真。在多个示例中，将FIR滤波器方法与用于去除水信号的HSVD方法进行了数值比较。结果表明，在大多数情况下，使用自动滤波器设计方案的FIR方法略优于HSVD方法。FIR滤波器方法的良好性能、易用性及其低计算复杂度促使人们使用所提出的方法。
