Piccolomini R, Catamo G, Di Placido G, D'Ercole S, Tumini V, Picciani C, Paolantonio M
Dipartimento di Scienze Biomediche, Università degli Studi G. d'Annunzio, Chieti, Italy.
New Microbiol. 1999 Jul;22(3):219-25.
The aim of this study was to evaluate the clinical and bacteriological effects of the intrasulcular application of a 1% metronidazole-gel (repeated administrations outdistanced of 7 days weeks long) currently employed in dermatological practice, to observe if a lower concentration of the chemotherapic agent could be equally effective as the 25% formulation in improving the periodontal condition of nine patients with adult periodontitis. The results showed that this regimen can modify, at a statistically significant level, the clinical (Pocket Probing Depth, Gingival Bleeding Index and Plaque Index) and bacteriological (Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia and Veillonella parvula) parameters associated with adult periodontitis. The results are similar to those obtainable with a 25% Metronidazole-gel administered two times outdistanced by 7 days.
本研究的目的是评估目前皮肤科实践中使用的1%甲硝唑凝胶龈沟内给药（重复给药间隔7天，为期数周）的临床和细菌学效果，观察较低浓度的化疗药物是否能与25%制剂一样有效改善9例成人牙周炎患者的牙周状况。结果表明，该治疗方案能在统计学显著水平上改变与成人牙周炎相关的临床参数（牙周袋探诊深度、牙龈出血指数和菌斑指数）和细菌学参数（伴放线放线杆菌、牙龈卟啉单胞菌、中间普氏菌和微小韦荣球菌）。结果与间隔7天给药两次的25%甲硝唑凝胶所获得的结果相似。
