Matto V, Skrebuhhova T, Allikmets L
Department of Pharmacology, University of Tartu, Estonia.
J Physiol Pharmacol. 1999 Jun;50(2):335-44.
The [3H]ketanserin binding characteristics in the apomorphine-induced aggressive and nonaggressive adult male Wistar rats were studied. Repeated apomorphine (0.5 mg/kg, once daily) treatment gradually induced aggressive behaviour in sixteen animals from twenty. Thereafter the animals were retrospectively divided into apomorphine-induced aggressive and nonaggressive group. The maximal number of the [3H]ketanserin binding sites was increased in the apomorphine-treated animals in the frontal (233.9+/-26.5, 364.6+/-31.7, and 367.0+/-34.8 fmol/mg protein for the vehicle, apomorphine-nonaggressive, and apomorphine-aggressive group, respectively) and cerebral cortex (164.2+/-6.7, 289.7+/-29.3, and 249.0+/-15.4 fmol/mg protein for the vehicle, apomorphine-nonaggressive, and apomorphine-aggressive group, respectively). In conclusion, our experiments demonstrate that repeated apomorphine treatment upregulates the maximal number of the 5-HT2A receptors in rat frontal and cerebral cortex as measured by [3H]ketanserin binding and this phenomenon is independent from the development of aggressive behaviour.
研究了阿扑吗啡诱导的成年雄性Wistar大鼠攻击性行为和非攻击性行为中的[3H]酮色林结合特性。对20只动物中的16只重复给予阿扑吗啡（0.5mg/kg，每日一次）治疗，逐渐诱导出攻击性行为。此后，将动物回顾性地分为阿扑吗啡诱导的攻击组和非攻击组。在阿扑吗啡处理的动物中，额叶（载体组、阿扑吗啡非攻击组和阿扑吗啡攻击组的[3H]酮色林结合位点最大数量分别为233.9±26.5、364.6±31.7和367.0±34.8fmol/mg蛋白）和大脑皮层（载体组、阿扑吗啡非攻击组和阿扑吗啡攻击组的[3H]酮色林结合位点最大数量分别为164.2±6.7、289.7±29.3和249.0±15.4fmol/mg蛋白）中[3H]酮色林结合位点的最大数量增加。总之，我们的实验表明，重复给予阿扑吗啡治疗可上调大鼠额叶和大脑皮层中5-HT2A受体的最大数量（通过[3H]酮色林结合测定），且这种现象与攻击性行为的发展无关。
