Datla K P, Mitra S K, Bhattacharya S K
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Indian J Exp Biol. 1991 Jul;29(7):631-5.
Footshock induced aggression (FIA) was induced in paired rats and three paradigms of aggressive behaviour were recorded, namely, latency to fight (LF), total period of physical contact (TPP) and cumulative aggression scores (CAS). The effects of increasing or decreasing central serotonergic activity, by using a number of pharmacological agents with well defined effects on rat brain serotonin, were investigated on FIA and on FIA augmented by apomorphine, a dopamine receptor agonist. The results show that centrally administered serotonin, the serotonin precursor, 5-hydroxytryptophan administered with clorgyline, a selective MAO A inhibitor, quipazine, a serotonin receptor agonist, and fluoxetine, a selective inhibitor of neuronal re-uptake of serotonin, attenuated all paradigms of FIA and apomorphine induced potentiation of FIA. On the contrary, the other re-uptake inhibitor used, citalopram, appeared to have a dual effect and decreased LF and CAS, while increasing TPP. The serotonin synthesis inhibitor, p-chlorophenylalanine and the selective serotonin receptor (5-HT2) antagonist, ketanserin, augmented all paradigms of FIA per se and apomorphine induced augmentation of FIA. However, the other serotonin receptor antagonist used, metergoline, which blocks both 5-HT1 and 5-HT2 receptor subtypes, attenuated FIA per se but decreased only CAS in apomorphine induced increase in FIA. The data confirm the inhibitory effect of the central serotonergic system on aggressive behaviour and the inverse relationship existing between it and the central dopaminergic system in the modulation of FIA, as has also been confirmed in earlier biochemical investigations from this laboratory. The data has been discussed in the light of existing knowledge on serotonin receptor subtypes and the presence of modulatory serotonergic heteroreceptors on central dopaminergic neurones.
在配对大鼠中诱导足部电击诱发攻击行为（FIA），记录三种攻击行为范式，即战斗潜伏期（LF）、身体接触总时长（TPP）和累积攻击得分（CAS）。使用多种对大鼠脑血清素具有明确作用的药理剂，研究增加或降低中枢5-羟色胺能活性对FIA以及对由多巴胺受体激动剂阿扑吗啡增强的FIA的影响。结果表明，中枢给予血清素、血清素前体5-羟色氨酸与选择性单胺氧化酶A抑制剂氯吉兰、血清素受体激动剂喹哌嗪以及血清素神经元再摄取选择性抑制剂氟西汀，均减弱了FIA的所有范式以及阿扑吗啡诱导的FIA增强作用。相反，所使用的另一种再摄取抑制剂西酞普兰似乎具有双重作用，它降低了LF和CAS，同时增加了TPP。血清素合成抑制剂对氯苯丙氨酸和选择性血清素受体（5-HT2）拮抗剂酮色林，本身增强了FIA的所有范式以及阿扑吗啡诱导的FIA增强作用。然而，所使用的另一种血清素受体拮抗剂麦角苄酯，它阻断5-HT1和5-HT2两种受体亚型，本身减弱了FIA，但在阿扑吗啡诱导的FIA增加中仅降低了CAS。数据证实了中枢5-羟色胺能系统对攻击行为的抑制作用，以及在FIA调节中它与中枢多巴胺能系统之间存在的反向关系，本实验室早期的生化研究也证实了这一点。已根据关于血清素受体亚型的现有知识以及中枢多巴胺能神经元上调节性5-羟色胺能异受体的存在对数据进行了讨论。
