Yamamoto H, Yube T, Isoda N, Sato Y, Sekine Y, Higashizawa T, Ido K, Kimura K, Kanai N
Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
Gastrointest Endosc. 1999 Aug;50(2):251-6. doi: 10.1016/s0016-5107(99)70234-8.
Saline-assisted endoscopic mucosal resection is an established therapeutic method. However, it is sometimes difficult to maintain a desired level of tissue elevation after injection of saline. Therefore we decided to use a mucinous substance such as sodium hyaluronate instead of saline.
Two resected porcine stomachs and five dogs were used for the study. The elevations, made by submucosal injections of sodium hyaluronate, were compared with those produced with normal saline. Sodium hyaluronate-assisted mucosal resections were compared with the saline-assisted resections.
Mucosal elevations created by submucosal injections of sodium hyaluronate remained for a longer time with a clearer margin compared to those made by saline injection. Endoscopic mucosal resections were performed safely with the assistance of sodium hyaluronate.
Use of sodium hyaluronate instead of saline for endoscopic mucosal resection could make the procedure easier and more reliable.
盐水辅助内镜黏膜切除术是一种成熟的治疗方法。然而，注射盐水后有时难以维持所需的组织隆起水平。因此，我们决定使用诸如透明质酸钠之类的黏液物质代替盐水。
使用两个切除的猪胃和五只狗进行研究。将通过黏膜下注射透明质酸钠产生的隆起与用生理盐水产生的隆起进行比较。将透明质酸钠辅助的黏膜切除术与盐水辅助的切除术进行比较。
与注射盐水相比，通过黏膜下注射透明质酸钠产生的黏膜隆起持续时间更长，边界更清晰。在内镜下，在透明质酸钠的辅助下安全地进行了黏膜切除术。
在内镜黏膜切除术中使用透明质酸钠代替盐水可使手术更简便、更可靠。
