Ernberg M, Hedenberg-Magnusson B, Alstergren P, Lundeberg T, Kopp S
Department of Clinical Oral Physiology, Karolinska Institutet, Stockholm, Sweden.
J Orofac Pain. 1999 Winter;13(1):56-62.
This study was conducted to investigate the serum level of serotonin (S-5-HT) in patients with temporomandibular disorders (TMD) of muscular origin, i.e., localized myalgia, and to compare it to that found in healthy individuals and patients with fibromyalgia. A second aim was to investigate the association between S-5-HT and pain parameters.
Twenty patients with localized myalgia participated in the study. Twenty age- and gender-matched healthy individuals and twenty patients with fibromyalgia served as controls. The participants were examined clinically as to the condition of the temporomandibular region and S-5-HT.
The levels of S-5-HT did not differ significantly between the groups. However, in patients with localized myalgia there was a negative correlation between S-5-HT and tenderness of the temporomandibular muscles.
The results of this study indicate that allodynia of orofacial muscles in patients with TMD is significantly related to S-5-HT concentration.
本研究旨在调查肌肉源性颞下颌关节紊乱病（TMD）患者，即局部肌痛患者的血清5-羟色胺（S-5-HT）水平，并将其与健康个体及纤维肌痛患者的该水平进行比较。第二个目的是研究S-5-HT与疼痛参数之间的关联。
20例局部肌痛患者参与了本研究。20例年龄和性别匹配的健康个体以及20例纤维肌痛患者作为对照。对参与者的颞下颌区域状况和S-5-HT进行了临床检查。
各组之间S-5-HT水平无显著差异。然而，在局部肌痛患者中，S-5-HT与颞下颌肌肉压痛之间存在负相关。
本研究结果表明，TMD患者口面部肌肉的痛觉过敏与S-5-HT浓度显著相关。
