Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanzavecchia A, Colonna M
Basel Institute for Immunology.
Nat Med. 1999 Aug;5(8):919-23. doi: 10.1038/11360.
We have identified two cell subsets in human blood based on the lack of lineage markers (lin-) and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and ILT3. One subset (lin-/ILT3+/ILT1+) is related to myeloid dendritic cells. The other subset (lin-/ILT3+/ILT1+) corresponds to 'plasmacytoid monocytes'. These cells are found in inflamed lymph nodes in and around the high endothelial venules. They express CD62L and CXCR3, and produce extremely large amounts of type I interferon after stimulation with influenza virus or CD40L. These results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon. Plasmacytoid monocytes may protect other cells from viral infections and promote survival of antigen-activated T cells.
基于谱系标志物的缺失（lin-）以及免疫球蛋白样转录受体1（ILT1）和ILT3的差异表达，我们在人血液中鉴定出了两个细胞亚群。一个亚群（lin-/ILT3+/ILT1+）与髓样树突状细胞相关。另一个亚群（lin-/ILT3+/ILT1+）对应于“浆细胞样单核细胞”。这些细胞存在于高内皮微静脉及其周围的炎症淋巴结中。它们表达CD62L和CXCR3，并在受到流感病毒或CD40L刺激后产生大量的I型干扰素。这些结果以及独特的细胞表型表明，浆细胞样单核细胞代表了一种特殊的细胞谱系，它在高内皮微静脉处进入炎症淋巴结，并在那里产生I型干扰素。浆细胞样单核细胞可能保护其他细胞免受病毒感染，并促进抗原激活的T细胞存活。
