Hoe N P, Nakashima K, Lukomski S, Grigsby D, Liu M, Kordari P, Dou S J, Pan X, Vuopio-Varkila J, Salmelinna S, McGeer A, Low D E, Schwartz B, Schuchat A, Naidich S, De Lorenzo D, Fu Y X, Musser J M
Institute for the Study of Human Bacterial Pathogenesis, Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Nat Med. 1999 Aug;5(8):924-9. doi: 10.1038/11369.
Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains recovered from population-based surveillance of infections in Canada, Finland and the United States. Epidemic waves are composed of strains expressing a remarkably heterogeneous array of variants of streptococcal inhibitor of complement that arise very rapidly by natural selection on mucosal surfaces. Thus, our results enhance the understanding of pathogen population dynamics in epidemic waves and infectious disease reemergence.
血清型M1 A群链球菌菌株引发了多次人类感染流行潮，长期以来人们一直认为这些感染是单克隆或寡克隆的。对从加拿大、芬兰和美国基于人群的感染监测中收集的1132株M1菌株进行了测序，这些菌株中编码一种抑制人类补体的细胞外A群链球菌蛋白（补体链球菌抑制剂）的基因。流行潮是由表达补体链球菌抑制剂变体的显著异质阵列的菌株组成，这些变体通过在粘膜表面的自然选择非常迅速地出现。因此，我们的结果增进了对流行潮中病原体种群动态和传染病再次出现的理解。
