血清粘蛋白抗原（CASA）作为胺碘酮所致肺毒性的标志物。
Serum mucin antigen (CASA) as a marker of amiodarone-induced pulmonary toxicity.
作者信息
Devine P L, Siebert W J, Morton S L, Scells B, Quin R J, Heddle W F, Zimmerman P V, Donohoe P J
机构信息
Department of Obstetrics & Gynaecology, University of Queensland, Brisbane, Australia.
出版信息
Dis Markers. 1998 Nov;14(3):169-75. doi: 10.1155/1998/496028.
Amiodarone is used to treat life-threatening cardiac arrhythmias. Amiodarone-induced pulmonary toxicity (APT) can be difficult to diagnose. APT may result in increased mucus production and mucin expression. Thus, serum mucin-1 was evaluated as a marker for amiodarone-induced pulmonary toxicity. Concentrations of mucin-1 in peripheral blood were determined using cancer-associated serum antigen (CASA) assay in patients taking amiodarone. Eight of ten patients who developed major amiodarone toxicity had high serum CASA levels. Patients with toxicity had a significantly higher mean rank CASA concentration compared with those without major toxicity. CASA shows potential as a marker for amiodarone-induced toxicity, particularly pulmonary toxicity.
胺碘酮用于治疗危及生命的心律失常。胺碘酮诱发的肺毒性（APT）可能难以诊断。APT可能导致黏液分泌增加和黏蛋白表达上调。因此，血清黏蛋白-1被评估为胺碘酮诱发肺毒性的标志物。采用癌症相关血清抗原（CASA）检测法测定服用胺碘酮患者外周血中黏蛋白-1的浓度。发生严重胺碘酮毒性反应的10例患者中有8例血清CASA水平较高。与无严重毒性反应的患者相比，发生毒性反应的患者CASA浓度的平均秩次显著更高。CASA显示出作为胺碘酮诱发毒性，尤其是肺毒性标志物的潜力。
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