Beaudeux J L
Laboratoire de Biochimie C, Hôpital de la Pitié, Groupe Hospitalier Pitié-Salpêtrière, Paris.
Ann Pharm Fr. 1999 May;57(3):266-75.
Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein with unknown functions, consisting of a low-density lipoprotein (LDL) core and the apo(a) glycoprotein. Apo(a) shares an homology with the fibrinolytic proenzyme plasminogen; the characteristic feature of apo(a) is the presence of multiple so called "kringles" repeats which are in part identical and in part exhibit slight sequence differences with regard to plasminogen. The atherothrombogenic properties of Lp(a) appear to be related either to its similarity to LDL (i.e., a proatherogenic effect) or to the apo(a) similarity to plasminogen (i.e., a prothrombotic/antifibrinolytic effect). Oxidative modification also could explain, at least partly, the participation of Lp(a) in the development of atheromatous lesions. In this review, we expose the main characteristics of in vitro oxidation of Lp(a), and the possible consequences on Lp(a) pathogenicity.
脂蛋白(a)[Lp(a)]是一种功能未知的致动脉粥样硬化脂蛋白，由低密度脂蛋白(LDL)核心和载脂蛋白(a)糖蛋白组成。载脂蛋白(a)与纤溶酶原这一纤维蛋白溶解酶原具有同源性；载脂蛋白(a)的特征是存在多个所谓的“kringle”重复序列，这些序列部分与纤溶酶原相同，部分在序列上与纤溶酶原有细微差异。Lp(a)的动脉粥样硬化血栓形成特性似乎与其与LDL的相似性(即促动脉粥样硬化作用)或载脂蛋白(a)与纤溶酶原的相似性(即促血栓形成/抗纤维蛋白溶解作用)有关。氧化修饰也至少可以部分解释Lp(a)在动脉粥样硬化病变发展中的作用。在这篇综述中，我们阐述了Lp(a)体外氧化的主要特征以及对Lp(a)致病性可能产生的后果。
