Colombero L T, Hariprashad J J, Tsai M C, Rosenwaks Z, Palermo G D
The Center for Reproductive Medicine and Infertility, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York 10021, USA.
Fertil Steril. 1999 Jul;72(1):90-6. doi: 10.1016/s0015-0282(99)00158-2.
To evaluate the incidence of sperm aneuploidy in men screened for infertility and identify any eventual relation with assisted reproductive outcome.
Controlled prospective study.
University hospital-based IVF program.
PATIENT(S): Infertile couples who were screened for sperm aneuploidy and evaluated for IVF treatment.
INTERVENTION(S): Fluorescence in situ hybridization was used to identify chromosomes 18, 21, X, and Y. The assisted reproductive techniques of IVF and intracytoplasmic sperm injection were used for infertility treatment.
MAIN OUTCOME MEASURE(S): The incidence of sperm aneuploidy, semen parameters, fertilization rate, pregnancy characteristics, and rate of neonatal malformations were determined.
RESULT(S): Oligozoospermic and teratozoospermic men had a significantly higher incidence of chromosomal abnormalities than men with normal semen parameters (2.7% vs. 1.8%). The increased frequency of sperm aneuploidy did not appear to affect pregnancy losses or the occurrence of neonatal malformations.
CONCLUSION(S): Suboptimal semen samples had a higher incidence of aneuploidy. In this study, the increased frequency of chromosomal abnormalities did not have a direct effect on the fertilization rate, pregnancy characteristics, or neonatal outcome.
评估接受不育筛查男性的精子非整倍体发生率，并确定其与辅助生殖结局之间的任何潜在关系。
对照前瞻性研究。
大学医院的体外受精项目。
接受精子非整倍体筛查并接受体外受精治疗评估的不育夫妇。
采用荧光原位杂交技术鉴定18号、21号、X和Y染色体。采用体外受精和卵胞浆内单精子注射辅助生殖技术治疗不育症。
测定精子非整倍体发生率、精液参数、受精率、妊娠特征和新生儿畸形率。
少精子症和畸形精子症男性的染色体异常发生率显著高于精液参数正常的男性（2.7%对1.8%）。精子非整倍体频率增加似乎并未影响妊娠丢失或新生儿畸形的发生。
精液样本质量欠佳者非整倍体发生率较高。在本研究中，染色体异常频率增加对受精率、妊娠特征或新生儿结局无直接影响。
