Heenen M
Département de Dermatologie, Hôpital Erasme, U.L.B.
Rev Med Brux. 1999 Jun;20(3):143-6.
Sun protection factor of sunscreens is assessed by their ability to inhibit UV-induced erythema. A correlation between sun sensitivity and density of DNA damage has been established. However the ability of suberythematous irradiation to induce DNA damage suggests that this correlation is not linear. Therefore, exposure to sunrays, extended because of a delayed erythema, can lead to more DNA damage than it is usually believed. The danger of long term of sunscreens use is therefore real, more especially as they may offer different protection factors for different biological end-points.
防晒霜的防晒系数是通过其抑制紫外线引起的红斑的能力来评估的。已经建立了阳光敏感性与DNA损伤密度之间的相关性。然而,亚红斑剂量照射诱导DNA损伤的能力表明这种相关性并非线性。因此,由于红斑延迟而延长的阳光照射可能导致比通常认为的更多的DNA损伤。因此,长期使用防晒霜的风险是真实存在的,尤其是因为它们可能对不同的生物学终点提供不同的保护系数。