Marinho R, Graça H, Ramalho F, Costa A, Batista A, de Moura M C
Hepatology Unit, Medicine 2, Hospital Santa Maria, Lisbon, Portugal.
Hepatogastroenterology. 1999 May-Jun;46(27):1949-52.
We report on 2 patients who showed mixed signs of primary biliary cirrhosis and autoimmune hepatitis. Both patients were female, in their fifties (54 and 58), their laboratory tests indicated cholestasis, and a liver biopsy revealed liver cirrhosis with significant lesions of the bile ducts. Both were treated with prednisolone with their liver tests showing a rapid normalization of their aminotransferases. These patients can be considered as presenting with what is known as the overlap syndrome or autoimmune cholangitis, which has the clinical, biochemical, immunological, and histopathological characteristics of primary biliary cirrhosis and autoimmune hepatitis type I.
我们报告了2例表现出原发性胆汁性肝硬化和自身免疫性肝炎混合症状的患者。两名患者均为女性，年龄五十多岁（分别为54岁和58岁），实验室检查显示胆汁淤积，肝脏活检显示肝硬化且胆管有明显病变。两人均接受泼尼松龙治疗，肝功能检查显示转氨酶迅速恢复正常。这些患者可被视为患有重叠综合征或自身免疫性胆管炎，其具有原发性胆汁性肝硬化和Ⅰ型自身免疫性肝炎的临床、生化、免疫和组织病理学特征。
