宿主对感染的抵抗力：Toll样受体基因对脂多糖反应性的遗传控制
Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes.
作者信息
Qureshi S T, Gros P, Malo D
机构信息
Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6.
出版信息
Trends Genet. 1999 Aug;15(8):291-4. doi: 10.1016/s0168-9525(99)01782-5.
Abstract
Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.
摘要
革兰氏阴性菌脂多糖在正常宿主体内引发保护性炎症反应。通过对突变小鼠的基因分析，编码Toll样受体4（Tlr4）的基因最近被确定为这种宿主防御机制的关键组成部分。Tlr4是一个古老基因家族的成员，该家族在植物、无脊椎动物和哺乳动物中调节抗菌宿主防御。
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