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Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function.细胞质动力蛋白的蛋白质磷酸化增加会导致运动功能受损。
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2
Comparison of the intracellular distribution of cytoplasmic dynein and kinesin in cultured cells: motor protein location does not reliably predict function.培养细胞中胞质动力蛋白和驱动蛋白的细胞内分布比较：运动蛋白的位置不能可靠地预测其功能。
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3
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Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport.大鼠肝细胞中转铁蛋白受体的再循环受蛋白磷酸酶2A调控，可能是通过对微管依赖性转运的影响来实现的。
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Role of phosphoprotein phosphatases in the corpus luteum: I identification and characterisation of serine/threonine phosphoprotein phosphatases in isolated rat luteal cells.磷蛋白磷酸酶在黄体中的作用：I. 分离的大鼠黄体细胞中丝氨酸/苏氨酸磷蛋白磷酸酶的鉴定与特性分析
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Dynein, dynactin, and kinesin II's interaction with microtubules is regulated during bidirectional organelle transport.在双向细胞器运输过程中，动力蛋白、动力蛋白激活蛋白和驱动蛋白II与微管的相互作用受到调控。
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本文引用的文献

1
Taxol inhibits endosomal-lysosomal membrane trafficking at two distinct steps in CV-1 cells.紫杉醇在CV-1细胞的两个不同步骤中抑制内体-溶酶体膜运输。
Am J Physiol. 1998 Dec;275(6):C1630-9. doi: 10.1152/ajpcell.1998.275.6.C1630.
2
Microtubule-dependent vesicle transport: modulation of channel and transporter activity in liver and kidney.微管依赖性囊泡运输：肝脏和肾脏中通道及转运体活性的调节
Physiol Rev. 1998 Oct;78(4):1109-29. doi: 10.1152/physrev.1998.78.4.1109.
3
Interaction of p59fyn kinase with the dynein light chain, Tctex-1, and colocalization during cytokinesis.p59fyn激酶与动力蛋白轻链Tctex-1的相互作用及胞质分裂过程中的共定位。
J Immunol. 1998 Aug 15;161(4):1728-37.
4
A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments.通过对稳定微管和波形蛋白中间丝的研究揭示了一种新型紫杉醇诱导的波形蛋白磷酸化和稳定化。
J Cell Sci. 1998 Jul;111 ( Pt 13):1841-52. doi: 10.1242/jcs.111.13.1841.
5
The role of the dynactin complex in intracellular motility.动力蛋白激活蛋白复合体在细胞内运动中的作用。
Int Rev Cytol. 1998;182:69-109. doi: 10.1016/s0074-7696(08)62168-3.
6
Kinesin and dynein superfamily proteins and the mechanism of organelle transport.驱动蛋白和动力蛋白超家族蛋白与细胞器运输机制
Science. 1998 Jan 23;279(5350):519-26. doi: 10.1126/science.279.5350.519.
7
Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC).一种新型人类丝氨酸/苏氨酸蛋白磷酸酶PP7的分子克隆、表达及特性分析，该蛋白与果蝇视网膜变性C基因产物（rdgC）同源。
J Biol Chem. 1998 Jan 16;273(3):1462-8. doi: 10.1074/jbc.273.3.1462.
8
Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport.大鼠肝细胞中转铁蛋白受体的再循环受蛋白磷酸酶2A调控，可能是通过对微管依赖性转运的影响来实现的。
Hepatology. 1997 Jul;26(1):176-85. doi: 10.1002/hep.510260123.
9
Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity.胆碱能刺激泪腺腺泡细胞可促进膜相关驱动蛋白和分泌蛋白β-己糖胺酶的重新分布，并增加驱动蛋白的运动活性。
Exp Eye Res. 1997 Feb;64(2):141-56. doi: 10.1006/exer.1996.0198.
10
Casein kinase II binds to and phosphorylates cytoplasmic dynein.酪蛋白激酶II与细胞质动力蛋白结合并使其磷酸化。
J Biol Chem. 1997 Feb 28;272(9):5887-91. doi: 10.1074/jbc.272.9.5887.

细胞质动力蛋白的蛋白质磷酸化增加会导致运动功能受损。

Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function.

作者信息

Runnegar M T, Wei X, Hamm-Alvarez S F

机构信息

Department of Medicine, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.

出版信息

Biochem J. 1999 Aug 15;342 ( Pt 1)(Pt 1):1-6.

PMID:10432292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1220428/
Abstract

Inhibition of serine/threonine protein phosphatases in rat hepatocytes by okadaic acid and microcystin increased the phosphorylation of several components of the cytoplasmic dynein complex. UV light/vanadate cleavage and Western blot analysis revealed that two of these components with molecular masses of approx. 400 kDa and 74 kDa were dynein heavy- and intermediate-chains respectively. This increased phosphorylation resulted in inhibition of dynein ATPase activity, and reduced motor-dependent avidity of endosomal/lysosomal membranes for microtubules.

摘要

冈田酸和微囊藻毒素对大鼠肝细胞中丝氨酸/苏氨酸蛋白磷酸酶的抑制作用增加了胞质动力蛋白复合体几个组分的磷酸化。紫外线/钒酸盐切割和蛋白质印迹分析表明，其中两个分子量分别约为400 kDa和74 kDa的组分分别是动力蛋白重链和中间链。这种磷酸化增加导致动力蛋白ATP酶活性受到抑制，并降低了内体/溶酶体膜对微管的运动依赖性亲和力。