Stasi M, Baiotto B, Palamara F, Gabriele P, Scielzo G
U.O.A. di Fisica Sanitaria, Ospedale Mauriziano Umberto L, Torino.
Radiol Med. 1999 May;97(5):382-8.
We studied the dosimetric characteristics of a multileaf collimator (MLC) installed on a dual energy accelerator with 6 and 18 MV photon beams in the Radiotherapy Department of Mauriziano Umberto I Hospital in Turin initiating its use in clinical practice. In particular, measurements included transmission through and between the leaves and at the junction under closed-leaves, central axis percentage depth dose, output factors and effective penumbra.
The MLC installed on the dual energy (6 and 18 MV) linear accelerator Varian Clinac 2100 C/D used in our radiotherapy department is an add-on component positioned below the standard jaws; it consists of 40 computer-controlled opposed pairs of 5 cm thick tungsten leaves, each projecting a 1 cm width at the isocenter, and it provides a maximum treatment field of 40 x 40 cm2 at 100 cm SAD. Transmission, penumbra and scalloping values were measured with the standard radiographic film routinary used in our department. A laser scanning photodensitometer (WP102, Wellhofer) with a 450 microns spot was used to obtain the optical density and the relative dose profile. Radiographic films had been calibrated with an ionization chamber, by irradiating samples to known doses; this calibration was used to correct the film scanner readings to dose. Percentage depth doses were also measured in an automatic water phantom (WP600, Wellhofer) for irregular fields defined by either MLC or alloy blocks, in order to test the differences in the build-up region due to the presence of the acrylic accessory tray. Measured and calculated output factors were compared for some irregular fields defined by the MLC. This comparison tested the algorithm accuracy of our Treatment Planning System 3D CadPlan 3.1.1 Varian-Dosetek.
For both energies, approximately 2% of the incident radiation on the MLC is transmitted and an additional 0.5% leakage occurs between adjacent leaves. The leakage under closed-leaves junction is remarkable: about 25-33%. Relative depth dose curves are similar for two fields shaped by either MLC or conventional jaws. Skin dose with MLC-shaped field is less (3.5%) than the one with cerrobend block-shaped fields. The monitor unit calculation procedure used in our treatment planning system can be applied to the MLC (the difference is less than 1%). Effective penumbra in MLC-shaped irregular fields is on the average 11 mm, which is slightly wider (2-3 mm) than the conventional cerrobend blocks penumbra. Effective penumbra increases with depth, field width and leaves positioning.
The MLC, if properly used (collimator rotation, jaws and leaves position, high number of fields), can be applied to conformal radiotherapy with good results. The MLC is better than conventional cerrobend blocks both to improve the treatment reproducibility and accuracy, and relative to dosimetric characteristics like dose transmission and skin dose. The use of MLC to modulate beam fluence (IMRT) will permit to modify beam intensity for improved shaping of the treated volume and to overcome the static therapy dosimetric limitations.
我们在都灵的毛里齐亚诺·翁贝托一世医院放疗科,对安装在配备6和18兆伏光子束的双能加速器上的多叶准直器(MLC)的剂量学特性进行了研究,该多叶准直器开始在临床实践中使用。具体而言,测量内容包括穿过叶片以及叶片之间的透射率、闭合叶片时交界处的透射率、中心轴百分深度剂量、输出因子和有效半值层。
我们放疗科使用的安装在双能(6和18兆伏)直线加速器瓦里安Clinac 2100 C/D上的多叶准直器是一个附加组件,位于标准准直器下方;它由40对计算机控制的相对的5厘米厚钨叶组成,每个叶在等中心处投影宽度为1厘米,在100厘米源轴距(SAD)时提供最大40×40平方厘米的治疗野。透射率、半值层和边缘凹凸值使用我们科室常规使用的标准射线照相胶片进行测量。使用具有450微米光斑的激光扫描光密度计(WP102,韦尔霍费尔)来获取光密度和相对剂量分布。射线照相胶片已通过电离室进行校准,通过将样品照射到已知剂量;此校准用于将胶片扫描仪读数校正为剂量。还在自动水模体(WP600,韦尔霍费尔)中测量了由多叶准直器或合金挡块定义的不规则野的百分深度剂量,以测试由于丙烯酸辅助托盘的存在而在建成区产生的差异。对多叶准直器定义的一些不规则野,比较了测量和计算的输出因子。此比较测试了我们的治疗计划系统3D CadPlan 3.1.1瓦里安 - 多西泰克的算法准确性。
对于两种能量,入射到多叶准直器上的辐射约2%被透射,相邻叶片之间额外有0.5%的泄漏。闭合叶片交界处的泄漏显著:约25 - 33%。由多叶准直器或传统准直器形成的两个野的相对深度剂量曲线相似。多叶准直器形成的野的皮肤剂量比铈基低熔点合金挡块形成的野的皮肤剂量小(3.5%)。我们治疗计划系统中使用的监测单位计算程序可应用于多叶准直器(差异小于1%)。多叶准直器形成的不规则野的有效半值层平均为11毫米,比传统铈基低熔点合金挡块的半值层略宽(2 - 3毫米)。有效半值层随深度、野宽和叶片位置增加。
如果正确使用(准直器旋转、准直器和叶片位置、大量野),多叶准直器可应用于适形放疗并取得良好效果。在提高治疗的可重复性和准确性以及剂量学特性如剂量透射和皮肤剂量方面,多叶准直器优于传统铈基低熔点合金挡块。使用多叶准直器调制射束注量(调强放疗)将允许改变射束强度以改善治疗体积的成形,并克服静态治疗剂量学限制。