脯氨酰4-羟化酶抑制剂（HOE 077）可预防大鼠肝纤维化中TIMP-1基因的表达。
Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis.
作者信息
Sakaida I, Uchida K, Hironaka K, Okita K
机构信息
First Department of Internal Medicine, School of Medicine, Yamaguchi University, Ube, Japan.
出版信息
J Gastroenterol. 1999 Jun;34(3):376-7. doi: 10.1007/s005350050277.
The effects of a prolyl 4-hydroxylase inhibitor (HOE 077) on tissue inhibitor of metalloproteinase-1 (TIMP-1) and procollagen type I were examined in rat liver fibrosis. HOE 077 (200 ppm) prevented fibrosis by inhibiting the expression of liver type I procollagen and TIMP-1 mRNAs, with liver hydroxyroline content correlated with the reduction in activated stellate cells. HOE 077 prevents fibrosis by inhibiting proline hydroxylation and stellate cell activation, resulting in reduced expression of procollagen and TIMP-1 mRNAs.
在大鼠肝纤维化模型中，研究了脯氨酰4-羟化酶抑制剂（HOE 077）对金属蛋白酶组织抑制剂-1（TIMP-1）和I型前胶原的影响。HOE 077（200 ppm）通过抑制肝I型前胶原和TIMP-1 mRNA的表达来预防纤维化，肝羟脯氨酸含量与活化星状细胞的减少相关。HOE 077通过抑制脯氨酸羟化和星状细胞活化来预防纤维化，从而导致前胶原和TIMP-1 mRNA的表达降低。
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