Pawelec G, Wagner W, Adibzadeh M, Engel A
Tübingen Ageing and Tumour Immunology Group, Second Department of Internal Medicine, Medizinische Universitätsklinik und Poliklinik, Germany.
Exp Gerontol. 1999 Jun;34(3):419-29. doi: 10.1016/s0531-5565(99)00002-9.
The term "immunosenescence" refers to an age-associated dysregulation of immune function which contributes to the increased susceptibility of the elderly to infectious disease. Although there are age-associated changes measurable in the innate immune system (Pawelec et al., 1998c), it is the adaptive, particularly T cell, system which is most susceptible to the deleterious effects of aging. In this minireview, characteristics of aging in long-term human T cell cultures will be summarized, and the parallels between the in vitro model and in vivo immunosenescence will be documented. The use of culture models to screen for ways of manipulating immunosenescence in vitro may provide a basis for intervention to ameliorate immunosenescence in vivo.
“免疫衰老”一词指的是与年龄相关的免疫功能失调，这导致老年人对传染病的易感性增加。尽管在固有免疫系统中可检测到与年龄相关的变化（帕韦莱克等人，1998年c），但适应性免疫系统，尤其是T细胞系统，最易受到衰老的有害影响。在这篇小型综述中，将总结长期人类T细胞培养中衰老的特征，并记录体外模型与体内免疫衰老之间的相似之处。利用培养模型筛选体外操纵免疫衰老的方法，可能为改善体内免疫衰老的干预措施提供依据。
