Solana R, Pawelec G
Department of Immunology, University Hospital Reina Sofia, Córdoba, Spain.
Mech Ageing Dev. 1998 May 15;102(2-3):115-29. doi: 10.1016/s0047-6374(98)00029-3.
Aged persons and most animals studied show a significant decline in the immune response primarily caused by changes in the T cell compartment. This decline in T cell function is due to a combination of factors: decreased production of new naive T cells by the involuting thymus; extensive antigen-induced activation leading to replicative senescence and clonal exhaustion of certain T cells; and postmitotic aging of resting T cells, a phenomenon also observed in other non-dividing cells such as neurons or muscle cells. The relative importance of these processes in the T cell defective immune response observed in aged humans and animals remains to be established although it is very likely that all of them participate in immunosenescence. The cellular, molecular biological basis and the clinical consequences of the defective immune response in aging were extensively discussed and reviewed at the 5th EUCAMBIS meeting. This paper summarizes the main presentations at the meeting. This special issue contains selected presentations from the congress, in the form of peer-reviewed full papers and the abstracts of two papers previously published in the journal.
老年人以及大多数被研究的动物显示出免疫反应显著下降，这主要是由T细胞区室的变化引起的。T细胞功能的这种下降是多种因素共同作用的结果：胸腺退化导致新的幼稚T细胞产生减少；广泛的抗原诱导激活导致某些T细胞复制性衰老和克隆耗竭；静息T细胞的有丝分裂后衰老，这种现象在其他非分裂细胞如神经元或肌肉细胞中也有观察到。尽管很可能所有这些过程都参与了免疫衰老，但这些过程在老年人和动物中观察到的T细胞缺陷性免疫反应中的相对重要性仍有待确定。在第五届欧洲衰老与生物标志物国际研讨会上，对衰老过程中免疫反应缺陷的细胞、分子生物学基础以及临床后果进行了广泛的讨论和综述。本文总结了会议上的主要报告内容。本期特刊以同行评审的全文和两篇先前发表在该杂志上的论文摘要的形式，收录了大会的部分报告。
