Chu H, Klemp A, Stille G
Psychopharmacology (Berl). 1978 Dec 8;59(3):309-10. doi: 10.1007/BF00426640.
In morphine-tolerant rats, a reappearance of morphine catalepsy and a disappearance of the turning behavior characteristic of brain-lesioned tolerant animals were observed under the influence of furosemide and spironolactone. The administration of spironolactone together with daily morphine treatment resulted first in an intensification of the morphine symptoms as measured by catalepsy and a retarded appearance of tolerance, typically characterized by a shift from catalepsy to turning movements in animals with single-sided brain lesions. Nontoxic doses of spironolactone raised the sensitivity of morphine-tolerant rats so that previously tolarated morphine doses become lethal.
在吗啡耐受的大鼠中，在速尿和螺内酯的影响下，观察到吗啡僵住症再次出现，并且脑损伤耐受动物特有的旋转行为消失。在每日给予吗啡的同时给予螺内酯，首先导致通过僵住症测量的吗啡症状加剧，以及耐受性出现延迟，其典型特征是单侧脑损伤动物从僵住症转变为旋转运动。无毒剂量的螺内酯提高了吗啡耐受大鼠的敏感性，使得先前耐受的吗啡剂量变得致命。
