Verneuil L, Boisseau-Garsaud A M, Desbois N, Garsaud P, Hélénon R, Calès-Quist D
Service de Dermatologie, Hôpital Pierre Zobda-Quitman, CHU, Fort-de-France, France.
Ann Dermatol Venereol. 1999 May;126(5):405-7.
Histoplasma capsulatum infection is considered to be endemic in the West Indies. Nevertheless, few epidemiologic studies have been conducted in this area. The histoplasmin skin test reflects the frequency of asymptomatic forms of histoplasmosis. We studied the prevalence of positive skin tests in a population of the French West Indies (Martinique).
Forty one patients (24 females and 17 males), age range 29 to 90 years, were tested for histoplasmin skin sensitivity between August and October 1997, in the department of dermatology of Fort de France (French West Indies). Patients with immunosuppression or personal history of histoplasmosis were excluded.
Five patients had a positive skin test (12 p. 100). No significative association was found between a positive skin test and diabetes, rural occupations or exposure to bats.
Despite the small number of cases, related with difficulties in obtaining histoplasmin, our study showed a sensitivity level similar to medium endemic areas of the USA. The positive skin test rate is much higher than the rate reported before in West Indies, in a sample of the population under 25 years of age.
荚膜组织胞浆菌感染在西印度群岛被认为是地方性疾病。然而,该地区进行的流行病学研究很少。组织胞浆菌素皮肤试验反映了无症状型组织胞浆菌病的发生频率。我们研究了法属西印度群岛(马提尼克岛)人群中皮肤试验阳性的患病率。
1997年8月至10月期间,在法兰西堡(法属西印度群岛)皮肤科对41例患者(24名女性和17名男性)进行了组织胞浆菌素皮肤敏感性检测,年龄范围为29至90岁。排除免疫抑制患者或有组织胞浆菌病个人史的患者。
5例患者皮肤试验呈阳性(12%)。皮肤试验阳性与糖尿病、农村职业或接触蝙蝠之间未发现显著关联。
尽管病例数量较少,且获取组织胞浆菌素存在困难,但我们的研究显示敏感性水平与美国中等流行地区相似。在25岁以下人群样本中,皮肤试验阳性率远高于之前在西印度群岛报道的率。