Toledo C, Alembik Y, Aguirre Jaime A, Stoll C
Service de Génétique Médicale, Centre Hospitalo-Universitaire, Strasbourg, France.
Ann Genet. 1999;42(2):81-90.
Growth curves of 105 children with Down syndrome (50 boys and 55 girls) were established. At birth height, weight and head circumference of Down syndrome children were lower than these parameters in controls. This delay remained stable until puberty. For weight there was no clear-cut pubertal growth spurt. For stature, the prepubertal growth spurt occurred earlier (at the age of 11 years in boys and 9 1/2 years in girls) than in controls but was less marked. As a result, Down syndrome patients had a short stature with a quite normal weight. These reference curves, available since prenatal diagnosis of Down syndrome is performed routinely, are helpful for monitoring normal and abnormal development in Down syndrome patients.
建立了105名唐氏综合征患儿（50名男孩和55名女孩）的生长曲线。唐氏综合征患儿出生时的身高、体重和头围低于对照组的这些参数。这种延迟在青春期前一直保持稳定。体重方面没有明显的青春期生长突增。身高方面，青春期前生长突增比对照组出现得更早（男孩为11岁，女孩为9.5岁），但不那么明显。结果，唐氏综合征患者身材矮小但体重相当正常。由于唐氏综合征的产前诊断已常规开展，这些参考曲线有助于监测唐氏综合征患者的正常和异常发育情况。
