Tworek J A, Goldblum J R, Weiss S W, Greenson J K, Appelman H D
Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA.
Am J Surg Pathol. 1999 Aug;23(8):937-45. doi: 10.1097/00000478-199908000-00012.
Stromal tumors of the abdominal colon, the least common of all gastrointestinal stromal tumors, have not been well characterized. They have often been lumped with stromal tumors of the anorectum in order to achieve significant numbers for analysis, yet there are no data to prove that stromal tumors from these two sites are the same. In this study, we evaluated 20 colonic stromal tumors to identify clinical, morphologic, and immunophenotypic features that were useful in discriminating between those that had metastasized or caused death from those that had not metastasized or caused death. We found that colonic stromal tumors are morphologically heterogeneous, and the malignant ones are clinically aggressive. They often have metastases at presentation, and cause death in a short time. An infiltrative growth pattern in the muscularis propria, invasion of the mucosa, and high mitotic counts correlated significantly both with metastases and with death from tumor. We also found that dense cellularity correlated significantly with metastases, but not with death, and that coagulative necrosis correlated with death, but not with metastases.
腹段结肠间质瘤是所有胃肠道间质瘤中最不常见的，其特征尚未得到充分描述。为了获得足够数量的样本进行分析，它们常常与直肠间质瘤归为一类，但目前尚无数据证明这两个部位的间质瘤是相同的。在本研究中，我们评估了20例结肠间质瘤，以确定有助于区分已发生转移或导致死亡的肿瘤与未发生转移或导致死亡的肿瘤的临床、形态学和免疫表型特征。我们发现结肠间质瘤在形态上具有异质性，恶性肿瘤在临床上具有侵袭性。它们在就诊时常常已经发生转移，并在短时间内导致死亡。固有肌层浸润性生长模式、黏膜侵犯和高核分裂象计数与转移及肿瘤致死均显著相关。我们还发现细胞密集程度与转移显著相关，但与死亡无关，而凝固性坏死与死亡相关，但与转移无关。
