脉冲剂量率近距离放射治疗肛管鳞状细胞癌。法国合作组的可行性研究。
Treatment of squamous cell anal canal carcinoma with pulsed dose rate brachytherapy. Feasibility study of a French cooperative group.
作者信息
Gerard J P, Mauro F, Thomas L, Castelain B, Mazeron J J, Ardiet J M, Peiffert D
机构信息
Service de Radiotherapie-Oncologie, Centre Hospitalier Lyon Sud, Pierre Benite, France.
出版信息
Radiother Oncol. 1999 May;51(2):129-31. doi: 10.1016/s0167-8140(99)00049-3.
BACKGROUND AND PURPOSE
To evaluate the feasibility of pulsed dose rate (PDR) brochytherapy in squamous cell anal canal carcinoma (SCACC).
MATERIALS AND METHODS
In this study a series of 19 patients with SCACC were included between 1995 and 1997. All patients were treated with curative intent with external beam radiotherapy (EBRT) (44-50 Gy) and one or two cycles of concomitant fluorouracilcisplatinum. After a gap of 2-3 weeks PDR interstitial brachytherapy was performed with a rigid needles technique. The dose was between 10-25 Gy (PARIS system).
RESULTS
All patients are alive. No severe grade 3-4 toxicity was encountered. One local relapse one metastatis were seen in two distinct patients. There was no dysfunction of the after loading machine.
CONCLUSION
The feasibility of PDR brachytherapy appears good in SCACC. It is an attractive alternative to low dose rate brachytherapy.
背景与目的
评估脉冲剂量率（PDR）近距离放射治疗肛管鳞状细胞癌（SCACC）的可行性。
材料与方法
本研究纳入了1995年至1997年间的19例肛管鳞状细胞癌患者。所有患者均接受根治性外照射放疗（EBRT）（44 - 50 Gy）以及一或两个周期的氟尿嘧啶和顺铂同步化疗。间隔2 - 3周后，采用刚性针技术进行PDR组织间近距离放射治疗。剂量为10 - 25 Gy（巴黎系统）。
结果
所有患者均存活。未出现严重的3 - 4级毒性反应。在两名不同患者中分别出现1例局部复发和1例转移。后装治疗机未出现功能障碍。
结论
PDR近距离放射治疗在肛管鳞状细胞癌中显示出良好的可行性。它是低剂量率近距离放射治疗的一个有吸引力的替代方案。
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