Snowden J S
Department of Neurology, Manchester Royal Infirmary, Manchester, UK.
Dement Geriatr Cogn Disord. 1999;10 Suppl 1:33-6. doi: 10.1159/000051209.
Semantic dementia, characterized by loss of word meaning and impaired face and object recognition, is one of the clinical manifestations of frontotemporal lobar degeneration and is associated with atrophy of the inferior and middle temporal gyri. Patients may present predominantly with problems in naming and understanding words, or in face and object recognition, the verbal or nonverbal predominance reflecting the accent of atrophy on the left or right temporal lobe. Behavioural changes may occur, although these have a more obsessional quality than is typically seen in frontotemporal dementia (FTD). However, overlap in clinical symptomatology of semantic dementia and FTD may occur with disease progression reinforcing the link between these clinical syndromes. Semantic dysfunction is poorly recognized and may be mistaken for the amnesia of Alzheimer's disease, yet may be important in explaining some of the behavioural characteristics seen in focal cerebral degeneration.
语义性痴呆以词义丧失、面部和物体识别受损为特征，是额颞叶变性的临床表现之一，与颞中下回萎缩有关。患者可能主要表现为命名和理解单词困难，或面部和物体识别困难，言语或非言语方面的优势反映了左侧或右侧颞叶萎缩的侧重。行为改变可能会出现，尽管这些改变比典型的额颞叶痴呆（FTD）具有更强迫性的特征。然而，随着疾病进展，语义性痴呆和FTD的临床症状可能会重叠，这加强了这些临床综合征之间的联系。语义功能障碍认识不足，可能被误诊为阿尔茨海默病的失忆症，但在解释局灶性脑变性中所见的一些行为特征方面可能很重要。
