趋化因子受体突变对异性间人类免疫缺陷病毒传播的影响。

Effect of chemokine receptor mutations on heterosexual human immunodeficiency virus transmission.

作者信息

Lockett S F, Alonso A, Wyld R, Martin M P, Robertson J R, Gore S M, Leen C L, Brettle R P, Yirrell D L, Carrington M, Brown A J

机构信息

Centre for HIV Research, Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh, Scotland.

出版信息

J Infect Dis. 1999 Sep;180(3):614-21. doi: 10.1086/314918.

DOI:10.1086/314918

PMID:10438347

Abstract

To assess the effect of mutations at the CCR-2 and CCR-5 loci on heterosexual human immunodeficiency virus (HIV) transmission, 144 persons heterosexually exposed to HIV (infected and uninfected [EU]) and 57 HIV-positive index partners were genotyped. A significantly higher frequency of 64I heterozygotes at CCR-2 was observed in HIV-positive than in EU women (P=.02, relative risk=1.6). The allele frequency of 64I in women was 8% in HIV-positive contacts and 1% in EUs (P<.02). At CCR-5, no difference in the frequency of Delta32 was seen between groups, and the CCR-5 genotypes did not differ in accumulated "at-risk" exposure in EUs. Combining the analysis of the Delta32 and 64I mutations in index partners suggested an additive effect on transmission (P=.10). Thus heterozygosity for 64I at CCR-2 acts as a risk factor for HIV infection of women after heterosexual contact but heterozygosity for Delta32 at CCR-5 has no detectable effect.

摘要

为评估CCR-2和CCR-5基因座突变对异性间人类免疫缺陷病毒（HIV）传播的影响，对144名异性接触HIV者（包括感染者和未感染者[EU]）以及57名HIV阳性的索引伴侣进行了基因分型。在HIV阳性女性中观察到CCR-2基因座64I杂合子的频率显著高于EU女性（P = 0.02，相对风险 = 1.6）。64I等位基因在HIV阳性接触者女性中的频率为8%，在EU女性中为1%（P < 0.02）。在CCR-5基因座，两组间Delta32频率无差异，且CCR-5基因型在EU中的累积“高危”暴露情况也无差异。对索引伴侣的Delta32和64I突变进行联合分析提示对传播有累加效应（P = 0.10）。因此，CCR-2基因座64I杂合性是异性接触后女性感染HIV的危险因素，但CCR-5基因座Delta32杂合性未显示出可检测到的影响。