CCR5-Δ32 杂合性对 HIV-1 易感性的影响：荟萃分析。
Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
机构信息
The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China.
出版信息
PLoS One. 2012;7(4):e35020. doi: 10.1371/journal.pone.0035020. Epub 2012 Apr 4.
BACKGROUND
So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility.
METHODS
We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility.
RESULTS
Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88-1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71-1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping.
CONCLUSIONS
The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.
背景
到目前为止，许多研究已经调查了 CCR5 基因型在 HIV-1 感染患者和未感染人群之间的分布。然而，关于 CCR5 基因 32 个碱基缺失的杂合性（CCR5-Δ32）是否会影响 HIV-1 易感性，尚未得出明确的结果。
方法
我们对包括 12000 多名 CCR5-Δ32 多态性基因分型的研究进行了荟萃分析。采用比值比（OR）和 95%置信区间（CI）来评估 CCR5-Δ32 多态性与 HIV-1 易感性的相关性。
结果
与野生型 CCR5 纯合子相比，CCR5-Δ32 杂合子在健康对照（HC）中的汇总 OR 为 1.02（95%CI，0.88-1.19），在暴露未感染对照（EU）中的汇总 OR 为 0.95（95%CI，0.71-1.26）。按种族、样本量和 CCR5-Δ32 基因分型方法进行分层分析，也得到了类似的结果。
结论
荟萃分析表明，CCR5-Δ32 的杂合性对 HIV-1 易感性没有显著影响。
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