来自缺乏X4毒株的快速进展者的1型人类免疫缺陷病毒R5毒株在人胸腺中不具有X4型致病性。
R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.
作者信息
Berkowitz R D, van't Wout A B, Kootstra N A, Moreno M E, Linquist-Stepps V D, Bare C, Stoddart C A, Schuitemaker H, McCune J M
机构信息
Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, USA.
出版信息
J Virol. 1999 Sep;73(9):7817-22. doi: 10.1128/JVI.73.9.7817-7822.1999.
Abstract
Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.
摘要
一些仅感染1型人类免疫缺陷病毒R5毒株的个体进展为艾滋病的速度与感染X4毒株的个体一样快。我们确定，在SCID-hu Thy/Liv小鼠中，三种R5病毒的致病性远低于一种X4病毒，这表明R5病毒介导的疾病快速进展与宿主因素而非病毒因素有关。
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