Pakhomova V O, Biloklyts'ka H F, Protunkevych O O, Rozanov V A, Pakhomova O O, Hruzova I L, Mel'nychuk D O
Institute of Stomatology, Ministry of Public Health of Ukraine, Odessa.
Fiziol Zh (1994). 1999;45(3):103-9.
Ions hydrogene concentration in fluids and tissues is one of the strict regulated physiological organism variables. Most common man and animal diseases are accompanied with compensated acid-base balance shift development. But diagnosis of metabolic acidosis and alkalosis with blood indices (pH, pCO2, HCO3) doesn't reflect true tissue condition that is connected not only with respiratory and excretion system functioning but with hypercompensation of metabolic processes. Excess organic acid formation in case of metabolic alkalosis formation in tissues directed to support pH leads to acidification, what brings an essential mistake in pathogenesis understanding of such diseases as cardiomyopathy, ischemic cardiac disease, myocardial infarction, hepatitis, collagenosis, caries, peptic ulcer, macula dystrophy, atherosclerosis, virus diseases, radiation damages. Ignorance primary tissue damages doesn't allow to conduct necessary preventive measures and to cure disease. It is suggested to assess development of metabolic acidosis and alkalosis by compensated changes of regulation acid-base homeostasis system, which is the basis of all future damages and development of different diseases against this background.
体液和组织中的氢离子浓度是生物体严格调控的生理变量之一。大多数常见的人类和动物疾病都伴随着代偿性酸碱平衡的变化。但是，通过血液指标（pH、pCO2、HCO3）诊断代谢性酸中毒和碱中毒并不能反映真正的组织状况，这不仅与呼吸和排泄系统的功能有关，还与代谢过程的过度代偿有关。在组织中形成代谢性碱中毒以维持pH值时，过量有机酸的形成会导致酸化，这在心肌病、缺血性心脏病、心肌梗死、肝炎、胶原病、龋齿、消化性溃疡、黄斑营养不良、动脉粥样硬化、病毒疾病、辐射损伤等疾病的发病机制理解上造成了重大错误。忽视原发性组织损伤就无法采取必要的预防措施和治愈疾病。建议通过酸碱稳态调节系统的代偿性变化来评估代谢性酸中毒和碱中毒的发展，这是在此背景下所有未来损伤和不同疾病发展的基础。
