巴西南部药用植物提取物的抗病毒活性。

Antiviral activity of south Brazilian medicinal plant extracts.

作者信息

Simões C M, Falkenberg M, Mentz L A, Schenkel E P, Amoros M, Girre L

机构信息

Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil.

出版信息

Phytomedicine. 1999 Jul;6(3):205-14. doi: 10.1016/S0944-7113(99)80010-5.

DOI:10.1016/S0944-7113(99)80010-5

PMID:10439486

Abstract

Brazilian plants are potential sources of useful edible and medicinal plants. Hydromethanolic extracts prepared from 54 medicinal plants used in folk medicine to treat infections were screened for antiviral properties against five different viruses (HSV-1, HSV-2, poliovirus type 2, adenovirus type 2 and VSV). Fifty-two percent of the plant extracts exhibited antiviral against one or more tested viruses. More specifically, 42.6% showed activity against HSV-1 (herpes simplex virus type 1), 42.6% against HSV-2 (herpes simplex virus type 2), 26% against poliovirus and 24% against VSV (vesicular stomatitis virus). None of the extracts was active against adenovirus. Trixis praestans (Vell.) Cabr. and Cunila spicata Benth. extracts were further characterized for antiviral activity.

摘要

巴西的植物是有用的食用和药用植物的潜在来源。对从54种用于民间医学治疗感染的药用植物中制备的氢甲醇提取物进行了针对五种不同病毒（单纯疱疹病毒1型、单纯疱疹病毒2型、2型脊髓灰质炎病毒、2型腺病毒和水疱性口炎病毒）的抗病毒特性筛选。52%的植物提取物对一种或多种测试病毒表现出抗病毒活性。更具体地说，42.6%对单纯疱疹病毒1型有活性，42.6%对单纯疱疹病毒2型有活性，26%对脊髓灰质炎病毒有活性，24%对水疱性口炎病毒有活性。没有提取物对腺病毒有活性。对普氏三裂叶（Vell.）卡布尔和穗花库尼拉提取物的抗病毒活性进行了进一步表征。